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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352399
Species: Homo sapiens
RGD Object: Gene
Symbol: ABCC4
Name: ATP binding cassette subfamily C member 4 (PEL blood group)
Acc ID: CHEBI:77319
Term: oltipraz
Definition: A 1,2-dithiole that is 3H-1,2-dithiole-3-thione substituted at positions 4 and 5 by methyl and pyrazin-2-yl groups respectively.
Chemical ID: MESH:C026209
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCC4increases expressionEXP 6480464CTDoltipraz results in increased expression of ABCC4 mRNA; oltipraz results in increased expression of ABCC4 proteinPMID:20395535 PMID:25752797
ABCC4multiple interactionsEXP 6480464CTDoltipraz promotes the reaction [ABCC4 protein results in increased transport of Arsenic]PMID:25752797
ABCC4increases expressionISOAbcc4 (Mus musculus)6480464CTDoltipraz results in increased expression of ABCC4 mRNAPMID:15833929 PMID:22496397
ABCC4multiple interactionsISOAbcc4 (Mus musculus)6480464CTD[Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC4 protein; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC4 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of ABCC4 mRNA]PMID:15833929 PMID:18032408 PMID:22496397
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