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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352399
Species: Homo sapiens
RGD Object: Gene
Symbol: ABCC4
Name: ATP binding cassette subfamily C member 4 (PEL blood group)
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCC4decreases expressionEXP 6480464CTDQuercetin results in decreased expression of ABCC4 mRNA; Quercetin results in decreased expression of ABCC4 proteinPMID:18624906
ABCC4decreases response to substanceEXP 6480464CTDABCC4 protein results in decreased susceptibility to QuercetinPMID:16156793
ABCC4multiple interactionsEXP 6480464CTDMefloquine inhibits the reaction [Quercetin results in increased activity of ABCC4 protein]; Quercetin affects the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Quercetin inhibits the reaction [ABCC4 protein results in decreased susceptibility to Thioguanine]; Quercetin inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]; Quercetin inhibits the reaction [Alprostadil promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]]; verlukast inhibits the reaction [Quercetin results in increased activity of ABCC4 protein]PMID:16004972 PMID:16156793
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