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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352097
Species: Homo sapiens
RGD Object: Gene
Symbol: POMC
Name: proopiomelanocortin
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
POMCincreases abundanceEXP 6480464CTDPOMC protein results in increased abundance of ProgesteronePMID:21332028
POMCmultiple interactionsEXP 6480464CTDMelatonin inhibits the reaction [POMC protein results in increased abundance of Progesterone]PMID:21332028
POMCincreases abundanceISOPomc (Mus musculus)6480464CTDPOMC protein results in increased abundance of ProgesteronePMID:19489000
POMCmultiple interactionsISOPomc (Mus musculus)6480464CTD[benzylphosphonic acid results in decreased activity of POMC protein] which results in decreased chemical synthesis of Progesterone; [oxophenylarsine results in decreased activity of POMC protein] which results in decreased chemical synthesis of Progesterone; HMOX1 protein inhibits the reaction [POMC protein results in increased abundance of Progesterone]PMID:12530643 PMID:19489000
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