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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352097
Species: Homo sapiens
RGD Object: Gene
Symbol: POMC
Name: proopiomelanocortin
Acc ID: CHEBI:16827
Term: corticosterone
Definition: A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
Chemical ID: MESH:D003345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
POMCdecreases abundanceISOPomc (Rattus norvegicus)6480464CTDPOMC protein results in decreased abundance of CorticosteronePMID:11518849
POMCdecreases secretionISOPomc (Rattus norvegicus)6480464CTDCorticosterone results in decreased secretion of POMC protein; POMC protein results in decreased secretion of CorticosteronePMID:12742521 PMID:3015567
POMCincreases abundanceISOPomc (Rattus norvegicus)6480464CTDPOMC protein results in increased abundance of CorticosteronePMID:10518784 PMID:7588239
POMCincreases secretionISOPomc (Mus musculus)6480464CTDPOMC protein modified form results in increased secretion of CorticosteronePMID:27052214
POMCincreases secretionISOPomc (Rattus norvegicus)6480464CTDPOMC protein modified form results in increased secretion of Corticosterone; POMC protein results in increased secretion of Corticosterone; POMC results in increased secretion of CorticosteronePMID:11132610 PMID:1659878 PMID:20837582
POMCmultiple interactionsISOPomc (Mus musculus)6480464CTDlipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]; resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]]PMID:27052214
POMCmultiple interactionsISOPomc (Rattus norvegicus)6480464CTDBromocriptine inhibits the reaction [POMC protein results in decreased secretion of Corticosterone]; Corticosterone inhibits the reaction [Nitroprusside results in increased secretion of POMC protein]; Cromolyn Sodium inhibits the reaction [POMC results in increased secretion of Corticosterone]; fulvestrant inhibits the reaction [nonylphenol promotes the reaction [POMC protein modified form results in increased secretion of Corticosterone]]; Nitroprusside inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]; nonylphenol inhibits the reaction [Nitroprusside inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]]; nonylphenol promotes the reaction [POMC protein modified form results in increased secretion of Corticosterone]; oxophenylarsine inhibits the reaction [POMC protein results in increased abundance of Corticosterone]; pervanadate inhibits the reaction [POMC protein results in increased abundance of Corticosterone]; SB 203580 inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]PMID:10518784 PMID:12742521 PMID:1659878 PMID:20837582 PMID:3015567
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