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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352024
Species: Homo sapiens
RGD Object: Gene
Symbol: CXCL10
Name: C-X-C motif chemokine ligand 10
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CXCL10decreases expressionEXP 6480464CTDCyclosporine results in decreased expression of CXCL10 mRNAPMID:20106945 PMID:27989131
CXCL10increases expressionISOCxcl10 (Mus musculus)6480464CTDCyclosporine results in increased expression of CXCL10 mRNAPMID:19770486 PMID:23958496 PMID:27585667
CXCL10increases expressionISOCxcl10 (Rattus norvegicus)6480464CTDCyclosporine results in increased expression of CXCL10 mRNAPMID:21865292
CXCL10multiple interactionsISOCxcl10 (Mus musculus)6480464CTDethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Cyclosporine results in increased expression of CXCL10 mRNA]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of CXCL10 mRNA]PMID:27585667
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