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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352010
Species: Homo sapiens
RGD Object: Gene
Symbol: CDK2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:34342
Term: 3-methylcholanthrene
Definition: A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Chemical ID: MESH:D008748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDK2decreases expressionEXP 6480464CTDMethylcholanthrene results in decreased expression of CDK2 proteinPMID:18022818
CDK2decreases methylationISOCdk2 (Rattus norvegicus)6480464CTDMethylcholanthrene results in decreased methylation of CDK2 promoterPMID:29094188
CDK2increases acetylationISOCdk2 (Rattus norvegicus)6480464CTDMethylcholanthrene results in increased acetylation of CDK2 promoterPMID:29094188
CDK2increases expressionISOCdk2 (Rattus norvegicus)6480464CTDMethylcholanthrene results in increased expression of CDK2 mRNAPMID:29094188
CDK2multiple interactionsISOCdk2 (Rattus norvegicus)6480464CTDalpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to CDK2 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased methylation of CDK2 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of CDK2 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CDK2 mRNA]; Methylcholanthrene promotes the reaction [AHR protein binds to CDK2 promoter]PMID:29094188
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