GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CDK2 | affects activity | EXP | | 6480464 | CTD | Doxorubicin affects the activity of CDK2 protein | PMID:16036217 | CDK2 | affects response to substance | EXP | | 6480464 | CTD | CDK2 protein affects the susceptibility to Doxorubicin | PMID:16036217 PMID:16217747 | CDK2 | decreases activity | EXP | | 6480464 | CTD | Doxorubicin results in decreased activity of CDK2 protein | PMID:25124555 | CDK2 | increases response to substance | EXP | | 6480464 | CTD | CDK2 protein results in increased susceptibility to Doxorubicin | PMID:15823547 | CDK2 | multiple interactions | EXP | | 6480464 | CTD | [Doxorubicin co-treated with TNF protein] results in increased activity of CDK2 protein; SETD7 protein inhibits the reaction [Doxorubicin results in decreased activity of CDK2 protein]; TP53 protein inhibits the reaction [Doxorubicin results in decreased activity of CDK2 protein] | PMID:15823547 PMID:25124555 | CDK2 | decreases response to substance | ISO | Cdk2 (Rattus norvegicus) | 6480464 | CTD | CDK2 protein results in decreased susceptibility to Doxorubicin | PMID:15124910 | CDK2 | increases activity | ISO | Cdk2 (Rattus norvegicus) | 6480464 | CTD | Doxorubicin results in increased activity of CDK2 protein | PMID:15124910 | CDK2 | increases phosphorylation | ISO | Cdk2 (Mus musculus) | 6480464 | CTD | Doxorubicin results in increased phosphorylation of CDK2 protein | PMID:15861398 | CDK2 | multiple interactions | ISO | Cdk2 (Rattus norvegicus) | 6480464 | CTD | [Roscovitine results in decreased activity of CDK2 protein] inhibits the reaction [TAF1 protein results in decreased susceptibility to Doxorubicin]; Doxorubicin promotes the reaction [CDK2 protein binds to FOXO1 protein modified form]; TAF1 protein mutant form inhibits the reaction [Doxorubicin results in increased activity of CDK2 protein]; TAF1 protein promotes the reaction [Doxorubicin results in increased activity of CDK2 protein] | PMID:15124910 PMID:32075913 | CDK2 | multiple interactions | ISO | Cdk2 (Mus musculus) | 6480464 | CTD | [Zoledronic Acid co-treated with Doxorubicin] results in decreased expression of CDK2 protein; Doxorubicin promotes the reaction [AZD 6244 results in decreased expression of CDK2 protein]; Doxorubicin promotes the reaction [CDK2 protein binds to FOXO1 protein]; PARP1 gene mutant form inhibits the reaction [Doxorubicin results in increased phosphorylation of CDK2 protein] | PMID:15861398 PMID:17876044 PMID:19789217 PMID:32075913 | | ||||||||||||||||||||||
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