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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1351854
Species: Homo sapiens
RGD Object: Gene
Symbol: CCL11
Name: C-C motif chemokine ligand 11
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCL11increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of CCL11 mRNA; Lipopolysaccharides results in increased expression of CCL11 proteinPMID:15460210 PMID:27568862
CCL11increases secretionEXP 6480464CTDLipopolysaccharides results in increased secretion of CCL11 proteinPMID:32800949
CCL11multiple interactionsEXP 6480464CTDcoagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of CCL11 protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL11 protein]; fexofenadine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL11 mRNA]; fexofenadine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL11 protein]PMID:15460210 PMID:27568862
CCL11increases expressionISOCcl11 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of CCL11 mRNAPMID:10027076
CCL11increases expressionISOCcl11 (Rattus norvegicus)6480464CTDLipopolysaccharides results in increased expression of CCL11 proteinPMID:33727093
CCL11increases secretionISOCcl11 (Mus musculus)6480464CTDLipopolysaccharides results in increased secretion of CCL11 proteinPMID:32800949
CCL11multiple interactionsISOCcl11 (Mus musculus)6480464CTD2'-hydroxyflavanone inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL11 protein]; bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CCL11 protein]; Lipopolysaccharides results in increased expression of and results in increased secretion of CCL11 proteinPMID:26918785 PMID:32800949
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