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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1351663
Species: Homo sapiens
RGD Object: Gene
Symbol: MIR23A
Name: microRNA 23a
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MIR23Aincreases expressionISOMir23a (Rattus norvegicus)6480464CTDDoxorubicin results in increased expression of MIR23A mRNAPMID:30831132
MIR23Amultiple interactionsISOMir23a (Rattus norvegicus)6480464CTDMIR23A mRNA affects the reaction [Doxorubicin results in decreased expression of PPARGC1A mRNA]; MIR23A mRNA affects the reaction [Doxorubicin results in decreased expression of PPARGC1A protein]; MIR23A mRNA affects the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; MIR23A mRNA affects the reaction [Doxorubicin results in increased phosphorylation of DNM1L protein]; PPARGC1A protein affects the reaction [MIR23A mRNA affects the reaction [Doxorubicin results in increased phosphorylation of DNM1L protein]]PMID:30831132
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