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GENE - TERM ANNOTATION REPORT

RGD ID: 1350921
Species: Homo sapiens
RGD Object: Gene
Symbol: AP2M1
Name: adaptor related protein complex 2 subunit mu 1
Acc ID: GO:0030122
Term: AP-2 adaptor complex
Definition: A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
Definition Source(s): GOC:mah, PMID:10611976, PMID:21097499, PMID:22022230, PMID:24322426
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AP2M1part_ofTAS 150520179BHF-UCL PMID:12121421

PMID:12121421
AP2M1located_inNAS 150520179ComplexPortal PMID:12086608

PMID:12086608
AP2M1part_ofIEAUniProtKB:P84091 or UniProtKB:P84092 or ensembl:ENSMUSP00000007216 or ensembl:ENSRNOP00000070202150520179Ensembl GO_REF:0000107
AP2M1part_ofIBAFB:FBgn0263351 or MGI:1298405 or PANTHER:PTN000242371 or Ap2m1 (Rattus norvegicus) or SGD:S000005423 or UniProtKB:Q96CW1 or dictyBase:DDB_G0277139150520179GO_Central GO_REF:0000033
AP2M1part_ofIEAPANTHER:PTHR10529:SF236150520179TreeGrafter GO_REF:0000118
AP2M1part_ofIDA 150520179UniProt PMID:23676497

PMID:23676497
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