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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350913
Species: Homo sapiens
RGD Object: Gene
Symbol: BNIP3
Name: BCL2 interacting protein 3
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BNIP3increases expressionEXP 6480464CTDcobaltous chloride results in increased expression of BNIP3 mRNAPMID:19320972 PMID:19376846 PMID:20105288 PMID:22269387
BNIP3multiple interactionsEXP 6480464CTDHIF1A mutant form inhibits the reaction [cobaltous chloride results in increased expression of BNIP3 mRNA]; peoniflorin inhibits the reaction [cobaltous chloride results in increased expression of BNIP3 mRNA]; tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of BNIP3 mRNA]PMID:22269387 PMID:25100165
BNIP3increases expressionISOBnip3 (Rattus norvegicus)6480464CTDcobaltous chloride results in increased expression of BNIP3 mRNAPMID:24386269
BNIP3increases expressionISOBnip3 (Mus musculus)6480464CTDcobaltous chloride results in increased expression of BNIP3 mRNA; cobaltous chloride results in increased expression of BNIP3 proteinPMID:15375294 PMID:17169330 PMID:23684559
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