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GENE - TERM ANNOTATION REPORT

RGD ID: 1350859
Species: Homo sapiens
RGD Object: Gene
Symbol: KRAS
Name: KRAS proto-oncogene, GTPase
Acc ID: DOID:0080764
Term: hereditary diffuse gastric cancer
Definition: A diffuse gastric cancer that is characterized by characterized by the development of diffuse (signet ring cell) gastric cancer at a young age, associated with germline heterozygous mutations of CDH1, MAP3K6 and CTNNA1 genes. (DO)
Definition Source(s): https://ghr.nlm.nih.gov/condition/hereditary-diffuse-gastric-cancer "DO" "DO", https://pubmed.ncbi.nlm.nih.gov/20591882/ "DO" "DO", https://rarediseases.info.nih.gov/diseases/10900/disease "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KRAS IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Hereditary diffuse gastric cancerPMID:12110640 PMID:14982869 PMID:17056636 PMID:17324647 PMID:18628094 PMID:20652921 PMID:20949621 PMID:24033266 PMID:24803665 PMID:25741868 PMID:28492532 PMID:29948256
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