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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350844
Species: Homo sapiens
RGD Object: Gene
Symbol: NR0B1
Name: nuclear receptor subfamily 0 group B member 1
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR0B1multiple interactionsISONr0b1 (Mus musculus)6480464CTD[[NR0B1 protein binds to STAR promoter] which results in decreased expression of STAR mRNA] which results in decreased abundance of Progesterone; NR0B1 protein inhibits the reaction [[Bucladesine results in increased expression of STAR protein] which results in increased abundance of Progesterone]; NR0B1 protein inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of STAR protein] which results in increased abundance of Progesterone]PMID:18787026
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