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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350750
Species: Homo sapiens
RGD Object: Gene
Symbol: SLCO1B3
Name: solute carrier organic anion transporter family member 1B3
Acc ID: CHEBI:28077
Term: rifampicin
Definition: A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei).
Chemical ID: MESH:D012293
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SLCO1B3decreases activityEXP 6480464CTDRifampin results in decreased activity of SLCO1B3 proteinPMID:31830554 PMID:32305507
SLCO1B3decreases expressionEXP 6480464CTDRifampin results in decreased expression of SLCO1B3 mRNAPMID:27199754
SLCO1B3multiple interactionsEXP 6480464CTDRifampin inhibits the reaction [SLCO1B3 protein results in increased import of cyanoginosin LR]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of epyrifenacil metabolite]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of estradiol-17 beta-glucuronide]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of fexofenadine]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Hydroxyurea]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Mesalamine]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Ursodeoxycholic Acid metabolite]PMID:17369605 PMID:18180276 PMID:21256917 PMID:21430235 PMID:31299240 PMID:32003934 PMID:32305507 PMID:34619012
SLCO1B3multiple interactionsISOSlco1b2 (Mus musculus)6480464CTDRifampin inhibits the reaction [SLCO1B2 protein results in increased uptake of epyrifenacil metabolite]PMID:34619012
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