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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350631
Species: Homo sapiens
RGD Object: Gene
Symbol: APEX2
Name: apurinic/apyrimidinic endodeoxyribonuclease 2
Acc ID: CHEBI:28217
Term: acrylonitrile
Definition: A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by an ethenyl group.
Chemical ID: MESH:D000181
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
APEX2increases expressionISOApex2 (Rattus norvegicus)6480464CTDAcrylonitrile results in increased expression of APEX2 mRNAPMID:26332274
APEX2multiple interactionsISOApex2 (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of APEX2 mRNA]; alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of APEX2 mRNA]; Plant Extracts inhibits the reaction [Acrylonitrile results in increased expression of APEX2 mRNA]PMID:26332274
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