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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350541
Species: Homo sapiens
RGD Object: Gene
Symbol: ESCO2
Name: establishment of sister chromatid cohesion N-acetyltransferase 2
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESCO2affects expressionISOEsco2 (Mus musculus)6480464CTDPhenobarbital affects the expression of ESCO2 mRNAPMID:19136022
ESCO2increases expressionISOEsco2 (Mus musculus)6480464CTDPhenobarbital results in increased expression of ESCO2 mRNAPMID:19482888 PMID:23091169 PMID:24690595 PMID:33549593
ESCO2multiple interactionsISOEsco2 (Mus musculus)6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of ESCO2 mRNA; [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of ESCO2 mRNA; NR1I3 protein affects the reaction [Phenobarbital results in increased expression of ESCO2 mRNA]PMID:19482888 PMID:24535843 PMID:33549593
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