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GENE - TERM ANNOTATION REPORT

RGD ID: 1350072
Species: Homo sapiens
RGD Object: Gene
Symbol: EIF3I
Name: eukaryotic translation initiation factor 3 subunit I
Acc ID: GO:0005852
Term: eukaryotic translation initiation factor 3 complex
Definition: A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs.
Definition Source(s): PMID:15904532
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EIF3Ilocated_inIPI 150520179ComplexPortal PMID:17322308

PMID:17322308
EIF3Ipart_ofIEAUniProtKB:Q9QZD9 or ensembl:ENSMUSP00000099653150520179Ensembl GO_REF:0000107
EIF3Ipart_ofIEAInterPro:IPR027525150520179InterPro GO_REF:0000002
EIF3Ipart_ofIDA 150520179UniProt PMID:17322308 PMID:17581632 PMID:18599441 PMID:25849773

PMID:17322308 PMID:17581632 PMID:18599441 PMID:25849773
EIF3Ipart_ofIEAUniRule:UR000107081150520179UniProt GO_REF:0000104
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