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GENE - TERM ANNOTATION REPORT

RGD ID: 1349823
Species: Homo sapiens
RGD Object: Gene
Symbol: HLA-DRB1
Name: major histocompatibility complex, class II, DR beta 1
Acc ID: DOID:526
Term: human immunodeficiency virus infectious disease
Definition: A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/HIV "DO" "DO", http://www.nlm.nih.gov/medlineplus/ency/article/000602.htm "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HLA-DRB1 IAGP 5147659RGDDNA:polymorphisms: :multiple (human) 
HLA-DRB1disease_progressionIAGP 5147591RGDDNA:polymorphism (human) 
HLA-DRB1susceptibilityIAGP 40903000RGDDNA:polymorphism:cds:HLA-DRB1*08, HLA-B*35, HLA-C*04 (human) 
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