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GENE - TERM ANNOTATION REPORT

RGD ID: 1349823
Species: Homo sapiens
RGD Object: Gene
Symbol: HLA-DRB1
Name: major histocompatibility complex, class II, DR beta 1
Acc ID: DOID:437
Term: myasthenia gravis
Definition: An autoimmune disease of the nervous system that has_material_basis_in antibodies to acetylcholine receptors at the neuromuscular junction, has_symptom ptosis, has_symptom diplopia, has_symptom dysphagia, has_symptom dysarthria, has_symptom muscle weakness and has_symptom shortness of breath. (DO)
Definition Source(s): https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Myasthenia-Gravis-Fact-Sheet "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HLA-DRB1onsetIAGP 7365079RGDDNA:polymorphism: :HLA-DRB1*0901, HLA-DRB1*1302(human) 
HLA-DRB1susceptibilityIAGP 7365051RGDDNA:polymorphism: :HLA-DRB1∗09,HLA- DRB1∗08(human) 
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