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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349699
Species: Homo sapiens
RGD Object: Gene
Symbol: TP53INP1
Name: tumor protein p53 inducible nuclear protein 1
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TP53INP1increases expressionEXP 6480464CTDFluorouracil results in increased expression of TP53INP1 mRNAPMID:16510598 PMID:16557594 PMID:17039268 PMID:17982676
TP53INP1multiple interactionsEXP 6480464CTDTP53 protein affects the reaction [Fluorouracil results in increased expression of TP53INP1 mRNA]; TP53 protein promotes the reaction [Fluorouracil results in increased expression of TP53INP1 mRNA]PMID:15016801 PMID:16557594 PMID:17982676
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