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GENE - TERM ANNOTATION REPORT

RGD ID: 1349690
Species: Homo sapiens
RGD Object: Gene
Symbol: TGM6
Name: transglutaminase 6
Acc ID: GO:0003810
Term: protein-glutamine gamma-glutamyltransferase activity
Definition: Catalysis of the reaction: L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4+. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
Definition Source(s): EC:2.3.2.13
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TGM6enablesIEAUniProtKB:Q8BM11 or ensembl:ENSMUSP00000028888150520179Ensembl GO_REF:0000107
TGM6enablesIBAFB:FBgn0031975 or MGI:1921395 or MGI:3044321 or MGI:98731 or PANTHER:PTN000904289 or UniProtKB:O95932 or UniProtKB:P00488 or UniProtKB:P21980 or UniProtKB:P22735 or UniProtKB:P51176 or UniProtKB:Q08188150520179GO_Central GO_REF:0000033
TGM6enablesIEAInterPro:IPR008958 or InterPro:IPR023608 or InterPro:IPR036238150520179InterPro GO_REF:0000002
TGM6enablesIDA 150520179MGI PMID:23206699

PMID:23206699
TGM6enablesIEARHEA:54816150520179RHEA GO_REF:0000116
TGM6enablesIEAPANTHER:PTHR11590:SF50150520179TreeGrafter GO_REF:0000118
TGM6enablesIEAEC:2.3.2.13150520179UniProt GO_REF:0000003
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