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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349615
Species: Homo sapiens
RGD Object: Gene
Symbol: PECAM1
Name: platelet and endothelial cell adhesion molecule 1
Acc ID: CHEBI:6980
Term: monocrotaline
Definition: A pyrrolizidine alkaloid that has formula C16H23NO6.
Chemical ID: MESH:D016686
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PECAM1decreases expressionISOPecam1 (Mus musculus)6480464CTDMonocrotaline results in decreased expression of PECAM1 mRNA; Monocrotaline results in decreased expression of PECAM1 proteinPMID:31470032 PMID:33122006
PECAM1multiple interactionsISOPecam1 (Mus musculus)6480464CTDromiplostim inhibits the reaction [Monocrotaline results in decreased expression of PECAM1 mRNA]; TBXA2R protein affects the reaction [Monocrotaline results in decreased expression of PECAM1 protein]; THPO protein inhibits the reaction [Monocrotaline results in decreased expression of PECAM1 mRNA]PMID:31470032 PMID:33122006
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