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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349475
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPA1A
Name: heat shock protein family A (Hsp70) member 1A
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPA1Aincreases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of HSPA1A mRNA; Benzo(a)pyrene results in increased expression of HSPA1A proteinPMID:18495319 PMID:20106945 PMID:22316170 PMID:22367790 PMID:26238291
HSPA1Aincreases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of HSPA1A exon; Benzo(a)pyrene results in increased methylation of HSPA1A promoterPMID:27901495
HSPA1Amultiple interactionsEXP 6480464CTDHSPA1A gene SNP results in increased susceptibility to [[Coke results in increased abundance of Air Pollutants, Occupational] which results in increased abundance of Benzo(a)pyrene]PMID:31730894
HSPA1Adecreases expressionISOHspa1a (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of HSPA1A mRNAPMID:27195522
HSPA1Aincreases expressionISOHspa1a (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of HSPA1A mRNAPMID:15894712 PMID:21569818
HSPA1Amultiple interactionsISOHspa1a (Mus musculus)6480464CTD[arsenite co-treated with Benzo(a)pyrene] results in increased expression of HSPA1A mRNA; [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of HSPA1A mRNA; [Benzo(a)pyrene co-treated with Dextran Sulfate] results in decreased expression of HSPA1A mRNAPMID:15894712 PMID:26271895 PMID:27858113
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