GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | HSPA1A | increases expression | EXP | | 6480464 | CTD | sodium arsenite results in increased expression of HSPA1A mRNA; sodium arsenite results in increased expression of HSPA1A protein | PMID:12016162 PMID:12760830 PMID:16729991 PMID:16966095 PMID:1742734 PMID:22354777 PMID:24516582 PMID:25087952 PMID:27068294 PMID:28229933 PMID:30309986 PMID:34032870 PMID:36586010 | HSPA1A | increases response to substance | EXP | | 6480464 | CTD | HSPA1A protein results in increased susceptibility to sodium arsenite | PMID:23708403 | HSPA1A | multiple interactions | EXP | | 6480464 | CTD | N-acetylglucosaminono-1,5-lactone O-(phenylcarbamoyl)oxime inhibits the reaction [sodium arsenite results in increased expression of HSPA1A mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of HSPA1A mRNA]; TP53 protein promotes the reaction [sodium arsenite results in increased expression of HSPA1A mRNA] | PMID:16966095 PMID:25087952 PMID:30309986 | HSPA1A | increases expression | ISO | Hspa1a (Mus musculus) | 6480464 | CTD | sodium arsenite results in increased expression of HSPA1A mRNA | PMID:12085988 PMID:16322246 PMID:36209798 | HSPA1A | increases expression | ISO | Hspa1a (Rattus norvegicus) | 6480464 | CTD | sodium arsenite results in increased expression of HSPA1A mRNA; sodium arsenite results in increased expression of HSPA1A protein | PMID:12388181 PMID:12690470 PMID:12842450 PMID:16729991 PMID:16815819 | HSPA1A | multiple interactions | ISO | Hspa1a (Mus musculus) | 6480464 | CTD | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in decreased expression of HSPA1A mRNA; CDKN1B protein inhibits the reaction [sodium arsenite results in increased expression of HSPA1A mRNA]; CDKN1B protein inhibits the reaction [sodium arsenite results in increased expression of HSPA1A protein]; HSF1 protein affects the reaction [sodium arsenite results in increased expression of HSPA1A protein]; JUN protein affects the reaction [sodium arsenite results in increased expression of HSPA1A protein]; MAPK9 protein affects the reaction [sodium arsenite results in increased expression of HSPA1A protein]; Quercetin inhibits the reaction [sodium arsenite results in increased expression of HSPA1A protein] | PMID:14606951 PMID:20566634 PMID:34876320 | HSPA1A | multiple interactions | ISO | Hspa1a (Rattus norvegicus) | 6480464 | CTD | chelerythrine inhibits the reaction [sodium arsenite results in increased expression of HSPA1A protein]; sodium arsenite inhibits the reaction [Cisplatin results in decreased expression of HSPA1A protein] | PMID:12690470 | |
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