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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349475
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPA1A
Name: heat shock protein family A (Hsp70) member 1A
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPA1Aincreases expressionEXP 6480464CTDsodium arsenite results in increased expression of HSPA1A mRNA; sodium arsenite results in increased expression of HSPA1A proteinPMID:12016162 PMID:12760830 PMID:16729991 PMID:16966095 PMID:1742734 PMID:22354777 PMID:24516582 PMID:25087952 PMID:27068294 PMID:28229933 PMID:30309986 PMID:34032870 PMID:36586010
HSPA1Aincreases response to substanceEXP 6480464CTDHSPA1A protein results in increased susceptibility to sodium arsenitePMID:23708403
HSPA1Amultiple interactionsEXP 6480464CTDN-acetylglucosaminono-1,5-lactone O-(phenylcarbamoyl)oxime inhibits the reaction [sodium arsenite results in increased expression of HSPA1A mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of HSPA1A mRNA]; TP53 protein promotes the reaction [sodium arsenite results in increased expression of HSPA1A mRNA]PMID:16966095 PMID:25087952 PMID:30309986
HSPA1Aincreases expressionISOHspa1a (Mus musculus)6480464CTDsodium arsenite results in increased expression of HSPA1A mRNAPMID:12085988 PMID:16322246 PMID:36209798
HSPA1Aincreases expressionISOHspa1a (Rattus norvegicus)6480464CTDsodium arsenite results in increased expression of HSPA1A mRNA; sodium arsenite results in increased expression of HSPA1A proteinPMID:12388181 PMID:12690470 PMID:12842450 PMID:16729991 PMID:16815819
HSPA1Amultiple interactionsISOHspa1a (Mus musculus)6480464CTD[sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in decreased expression of HSPA1A mRNA; CDKN1B protein inhibits the reaction [sodium arsenite results in increased expression of HSPA1A mRNA]; CDKN1B protein inhibits the reaction [sodium arsenite results in increased expression of HSPA1A protein]; HSF1 protein affects the reaction [sodium arsenite results in increased expression of HSPA1A protein]; JUN protein affects the reaction [sodium arsenite results in increased expression of HSPA1A protein]; MAPK9 protein affects the reaction [sodium arsenite results in increased expression of HSPA1A protein]; Quercetin inhibits the reaction [sodium arsenite results in increased expression of HSPA1A protein]PMID:14606951 PMID:20566634 PMID:34876320
HSPA1Amultiple interactionsISOHspa1a (Rattus norvegicus)6480464CTDchelerythrine inhibits the reaction [sodium arsenite results in increased expression of HSPA1A protein]; sodium arsenite inhibits the reaction [Cisplatin results in decreased expression of HSPA1A protein]PMID:12690470
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