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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349475
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPA1A
Name: heat shock protein family A (Hsp70) member 1A
Acc ID: CHEBI:27363
Term: zinc atom
Definition: A zinc group element atom that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPA1Aincreases expressionEXP 6480464CTDZinc results in increased expression of HSPA1A mRNAPMID:16870260 PMID:17244614
HSPA1Amultiple interactionsEXP 6480464CTD[PCI 5002 co-treated with Zinc] results in increased expression of HSPA1A mRNA; Zinc promotes the reaction [HSF1 protein binds to HSPA1A enhancer]; Zinc promotes the reaction [HSF1 protein binds to HSPA1A promoter]PMID:16460681 PMID:17244614 PMID:18593933
HSPA1Aincreases expressionISOHspa1a (Rattus norvegicus)6480464CTDZinc results in increased expression of HSPA1A mRNA; Zinc results in increased expression of HSPA1A proteinPMID:15159208 PMID:16949620
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