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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349475
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPA1A
Name: heat shock protein family A (Hsp70) member 1A
Acc ID: CHEBI:22977
Term: cadmium atom
Definition: A zinc group element atom that has formula Cd.
Chemical ID: MESH:D002104
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPA1Aincreases expressionEXP 6480464CTDCadmium results in increased expression of HSPA1A mRNA; Cadmium results in increased expression of HSPA1A proteinPMID:16729991 PMID:17244614 PMID:21172416 PMID:22562489 PMID:24284285 PMID:33559965 PMID:8917683
HSPA1Amultiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HSPA1A mRNA; Cadmium promotes the reaction [HSF1 protein binds to HSPA1A enhancer]; Cadmium promotes the reaction [HSF1 protein binds to HSPA1A promoter]PMID:16460681 PMID:17244614 PMID:31738976
HSPA1Aincreases expressionISOHspa1a (Rattus norvegicus)6480464CTDCadmium results in increased expression of HSPA1A proteinPMID:16729991
HSPA1Amultiple interactionsISOHspa1a (Mus musculus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HSPA1A mRNAPMID:37325564
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