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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349475
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPA1A
Name: heat shock protein family A (Hsp70) member 1A
Acc ID: CHEBI:16842
Term: formaldehyde
Definition: An aldehyde resulting from the formal oxidation of methanol.
Chemical ID: MESH:D005557
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPA1Adecreases expressionEXP 6480464CTDFormaldehyde results in decreased expression of HSPA1A mRNA; Formaldehyde results in decreased expression of HSPA1A proteinPMID:27664576 PMID:30600586
HSPA1Aincreases expressionEXP 6480464CTDFormaldehyde results in increased expression of HSPA1A mRNAPMID:20655997 PMID:22367790 PMID:23649840
HSPA1Amultiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[HSPA1A protein co-treated with Formaldehyde] results in increased phosphorylation of AKT1 protein]; [HSPA1A protein co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Formaldehyde] results in increased expression of GLI2 protein; [HSPA1A protein co-treated with Formaldehyde] results in increased expression of GLI2 protein; [HSPA1A protein co-treated with Formaldehyde] results in increased phosphorylation of AKT1 proteinPMID:30600586
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