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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349475
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPA1A
Name: heat shock protein family A (Hsp70) member 1A
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPA1Adecreases expressionEXP 6480464CTDQuercetin results in decreased expression of HSPA1A mRNA; Quercetin results in decreased expression of HSPA1A proteinPMID:17234771 PMID:21632981
HSPA1Aincreases expressionEXP 6480464CTDQuercetin results in increased expression of HSPA1A proteinPMID:14750173
HSPA1Aincreases response to substanceEXP 6480464CTDHSPA1A mutant form results in increased susceptibility to QuercetinPMID:24126416
HSPA1Amultiple interactionsEXP 6480464CTD[Quercetin co-treated with Ascorbic Acid] results in increased expression of HSPA1A mRNA; HSPA1A mutant form results in increased susceptibility to [Quercetin co-treated with temozolomide]PMID:17639512 PMID:24126416
HSPA1Aaffects expressionISOHspa1a (Mus musculus)6480464CTDQuercetin affects the expression of HSPA1A proteinPMID:14606951
HSPA1Adecreases expressionISOHspa1a (Mus musculus)6480464CTDQuercetin results in decreased expression of HSPA1A mRNAPMID:17349211
HSPA1Amultiple interactionsISOHspa1a (Mus musculus)6480464CTDQuercetin inhibits the reaction [Hydrogen Peroxide affects the localization of HSPA1A protein]; Quercetin inhibits the reaction [Hydrogen Peroxide promotes the reaction [HSPA1A protein binds to HMGB1 protein]]; Quercetin inhibits the reaction [sodium arsenite results in increased expression of HSPA1A protein]PMID:14606951 PMID:17513788
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