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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349475
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPA1A
Name: heat shock protein family A (Hsp70) member 1A
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPA1Aaffects expressionEXP 6480464CTDHydrogen Peroxide affects the expression of HSPA1A mRNAPMID:20044591
HSPA1Aincreases expressionEXP 6480464CTDHydrogen Peroxide results in increased expression of HSPA1A mRNAPMID:12414654 PMID:30309986 PMID:34581912
HSPA1Amultiple interactionsEXP 6480464CTDHydrogen Peroxide promotes the reaction [HSPA1A protein binds to HMGB1 protein]PMID:17513788
HSPA1Aaffects localizationISOHspa1a (Mus musculus)6480464CTDHydrogen Peroxide affects the localization of HSPA1A proteinPMID:17513788
HSPA1Amultiple interactionsISOHspa1a (Mus musculus)6480464CTDHSPA1A protein inhibits the reaction [Hydrogen Peroxide affects the localization of HMGB1 protein]; HSPA1A protein inhibits the reaction [Hydrogen Peroxide results in increased secretion of HMGB1 protein]; Hydrogen Peroxide promotes the reaction [HSPA1A protein binds to HMGB1 protein]; Quercetin inhibits the reaction [Hydrogen Peroxide affects the localization of HSPA1A protein]; Quercetin inhibits the reaction [Hydrogen Peroxide promotes the reaction [HSPA1A protein binds to HMGB1 protein]]PMID:17513788
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