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GENE - TERM ANNOTATION REPORT

RGD ID: 1349400
Species: Homo sapiens
RGD Object: Gene
Symbol: HECW2
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Acc ID: GO:0061630
Term: ubiquitin protein ligase activity
Definition: Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
Definition Source(s): GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HECW2enablesIBAFB:FBgn0003557 or FB:FBgn0029006 or FB:FBgn0259174 or FB:FBgn0261931 or MGI:1861728 or MGI:1914144 or MGI:1933754 or MGI:97297 or PANTHER:PTN008515277 or PomBase:SPAC11G7.02 or PomBase:SPAC1805.15c or SGD:S000000927 or UniProtKB:O15033 or UniProtKB:P46934 or UniProtKB:Q7Z6Z7 or UniProtKB:Q96J02 or UniProtKB:Q9HAU4 or UniProtKB:Q9HCE7150520179GO_Central GO_REF:0000033
HECW2enablesIEAInterPro:IPR024928150520179InterPro GO_REF:0000002
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