Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349244
Species: Homo sapiens
RGD Object: Gene
Symbol: PLN
Name: phospholamban
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PLNaffects expressionISOPln (Rattus norvegicus)6480464CTDbisphenol A affects the expression of PLN mRNAPMID:25181051
PLNdecreases expressionISOPln (Mus musculus)6480464CTDbisphenol A results in decreased expression of PLN mRNAPMID:32156529
PLNdecreases phosphorylationISOPln (Mus musculus)6480464CTDbisphenol A results in decreased phosphorylation of PLN proteinPMID:31685870
PLNincreases expressionISOPln (Mus musculus)6480464CTDbisphenol A results in increased expression of PLN proteinPMID:23418087
PLNincreases methylationISOPln (Rattus norvegicus)6480464CTDbisphenol A results in increased methylation of PLN genePMID:28505145
PLNincreases phosphorylationISOPln (Rattus norvegicus)6480464CTDbisphenol A results in increased phosphorylation of PLN proteinPMID:24140712 PMID:28324061
PLNmultiple interactionsISOPln (Rattus norvegicus)6480464CTDMifepristone inhibits the reaction [Progesterone inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]]; Mifepristone inhibits the reaction [progesterone-11-bovine serum albumin inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]]; Pertussis Toxin inhibits the reaction [Progesterone inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]]; Progesterone inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]; progesterone-11-bovine serum albumin inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]; wortmannin inhibits the reaction [Progesterone inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]]PMID:28324061
Go Back to source page   Continue to Ontology report