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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349200
Species: Homo sapiens
RGD Object: Gene
Symbol: GSTA1
Name: glutathione S-transferase alpha 1
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSTA1decreases expressionISOGsta1 (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in decreased expression of GSTA1 mRNAPMID:31150632 PMID:31168027
GSTA1multiple interactionsISOGsta1 (Rattus norvegicus)6480464CTD[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased activity of GSTA1 protein; Ketoconazole inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSTA1 mRNA]; Tea inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased activity of GSTA1 protein]PMID:12725062 PMID:31168027
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