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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348646
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A5
Name: cytochrome P450 family 3 subfamily A member 5
Acc ID: CHEBI:34202
Term: 2,2',4,4',5,5'-hexachlorobiphenyl
Definition: A hexachlorobiphenyl that has formula C12H4Cl6.
Chemical ID: MESH:C014024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A5increases expressionISOCyp3a13 (Mus musculus)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of CYP3A13 mRNAPMID:21851831
CYP3A5multiple interactionsISOCyp3a9 (Rattus norvegicus)6480464CTD[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of CYP3A13 mRNAPMID:16984957
CYP3A5multiple interactionsISOCyp3a13 (Mus musculus)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP3A13 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of CYP3A13 mRNA]PMID:21851831
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