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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348634
Species: Homo sapiens
RGD Object: Gene
Symbol: MIR17
Name: microRNA 17
Acc ID: CHEBI:17234
Term: glucose
Definition: An aldohexose used as a source of energy and metabolic intermediate.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MIR17decreases expressionISOMir17 (Mus musculus)6480464CTDGlucose results in decreased expression of MIR17 mRNAPMID:26660634
MIR17multiple interactionsISOMir17 (Mus musculus)6480464CTD[[[[Glucose results in decreased expression of MIR17 mRNA] which results in increased expression of TXNIP mRNA] which results in increased expression of TXNIP protein] promotes the reaction [TXNIP protein binds to TXN1 protein]] which results in increased activity of MAP3K5 protein; [Glucose results in decreased expression of MIR17 mRNA] which results in increased expression of TXNIP mRNA; [Glucose results in decreased expression of MIR17 mRNA] which results in increased stability of TXNIP proteinPMID:26660634
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