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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348590
Species: Homo sapiens
RGD Object: Gene
Symbol: CGA
Name: glycoprotein hormones, alpha polypeptide
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CGAmultiple interactionsEXP 6480464CTD[Plant Extracts co-treated with Resveratrol] results in decreased expression of CGA mRNA; [Resveratrol analog co-treated with CGA protein] results in increased secretion of Progesterone; [Resveratrol co-treated with CGA protein] results in increased secretion of Progesterone; Resveratrol analog inhibits the reaction [CGA protein results in increased expression of STAR protein]; Resveratrol analog inhibits the reaction [CGA protein results in increased secretion of Testosterone]; Resveratrol inhibits the reaction [CGA protein results in increased secretion of Testosterone]PMID:19603415 PMID:23557933
CGAmultiple interactionsISOCga (Rattus norvegicus)6480464CTD[[resveratrol analog co-treated with CGA protein] results in decreased expression of CYP17A1 protein] which results in increased secretion of Progesterone; [[resveratrol co-treated with CGA protein] results in decreased expression of CYP17A1 protein] which results in increased secretion of Progesterone; [resveratrol analog co-treated with CGA protein] results in decreased expression of CYP17A1 protein; [resveratrol co-treated with CGA protein] results in decreased expression of CYP17A1 proteinPMID:19603415
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