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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348463
Species: Homo sapiens
RGD Object: Gene
Symbol: EP300
Name: E1A binding protein p300
Acc ID: CHEBI:15551
Term: prostaglandin E2
Definition: Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.
Chemical ID: MESH:D015232
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EP300multiple interactionsEXP 6480464CTDDinoprostone promotes the reaction [EP300 protein binds to CYP19A1 promoter]; Dinoprostone promotes the reaction [HIF1A protein binds to EP300 protein]; KAT2B protein affects the reaction [Dinoprostone promotes the reaction [EP300 protein binds to CYP19A1 promoter]]; KAT2B protein affects the reaction [Dinoprostone promotes the reaction [HIF1A protein binds to EP300 protein]]; SIRT1 protein inhibits the reaction [Dinoprostone promotes the reaction [EP300 protein binds to CYP19A1 promoter]]; SIRT1 protein inhibits the reaction [Dinoprostone promotes the reaction [HIF1A protein binds to EP300 protein]]PMID:30409902
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