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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348452
Species: Homo sapiens
RGD Object: Gene
Symbol: XDH
Name: xanthine dehydrogenase
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
XDHincreases activityEXP 6480464CTDQuercetin results in increased activity of XDH protein alternative formPMID:19215233
XDHmultiple interactionsISOXdh (Rattus norvegicus)6480464CTDQuercetin inhibits the reaction [[Streptozocin affects the activity of XDH protein] which results in increased chemical synthesis of Hydrogen Peroxide]; Quercetin inhibits the reaction [[Xanthine co-treated with XDH protein] results in increased cleavage of CASP3 protein]; Quercetin inhibits the reaction [[Xanthine co-treated with XDH protein] results in increased phosphorylation of MAPKAPK2 protein]; Quercetin inhibits the reaction [Petroleum results in increased activity of XDH protein]; Quercetin inhibits the reaction [Streptozocin affects the activity of XDH protein]PMID:23647015 PMID:25046308 PMID:26374991
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