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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348437
Species: Homo sapiens
RGD Object: Gene
Symbol: MMP9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MMP9affects expressionEXP 6480464CTDQuercetin affects the expression of MMP9 mRNAPMID:32530119
MMP9decreases activityEXP 6480464CTDQuercetin results in decreased activity of MMP9 proteinPMID:22871832
MMP9decreases expressionEXP 6480464CTDQuercetin results in decreased expression of MMP9 mRNA; Quercetin results in decreased expression of MMP9 proteinPMID:22871832 PMID:25481090 PMID:27279714 PMID:37147755
MMP9decreases secretionEXP 6480464CTDQuercetin results in decreased secretion of MMP9 proteinPMID:15135307
MMP9increases expressionEXP 6480464CTDQuercetin results in increased expression of MMP9 proteinPMID:10556937
MMP9multiple interactionsEXP 6480464CTDQuercetin analog inhibits the reaction [24-hydroxycholesterol results in increased expression of MMP9 mRNA]; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of MMP9 mRNA]; Quercetin analog inhibits the reaction [cholest-5-en-3 beta,7 alpha-diol results in increased expression of MMP9 mRNA]; Quercetin inhibits the reaction [EGF protein results in increased secretion of MMP9 protein]; Quercetin inhibits the reaction [IL1B protein results in increased expression of MMP9 protein]; Quercetin inhibits the reaction [nickel chloride results in increased expression of and results in increased activity of MMP9 protein]; Quercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; Quercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; Quercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; Quercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]; Quercetin inhibits the reaction [TNF protein results in increased activity of MMP9 protein]; Quercetin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Quercetin promotes the reaction [prolinedithiocarbamate results in decreased expression of MMP9 protein]; Quercetin promotes the reaction [TLR4 protein affects the expression of MMP9 protein]; Quercetin results in decreased expression of and results in decreased activity of MMP9 protein; Quercetin results in decreased expression of and results in decreased secretion of MMP9 protein; Tamoxifen affects the reaction [Quercetin affects the expression of MMP9 mRNA]PMID:12589822 PMID:15135307 PMID:18628248 PMID:19804834 PMID:22595400 PMID:22871832 PMID:23645742 PMID:24802026 PMID:27279714 PMID:30016632 PMID:32530119
MMP9decreases activityISOMmp9 (Mus musculus)6480464CTDQuercetin results in decreased activity of MMP9 proteinPMID:14593496 PMID:24275163
MMP9decreases expressionISOMmp9 (Mus musculus)6480464CTDQuercetin results in decreased expression of MMP9 mRNAPMID:16304905 PMID:24275163
MMP9multiple interactionsISOMmp9 (Rattus norvegicus)6480464CTD[Quercetin co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [Ethanol results in increased expression of and results in increased activity of MMP9 protein]; [Quercetin co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [Ethanol results in increased secretion of MMP9 protein]; Quercetin inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased activity of MMP9 protein]; Quercetin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of MMP9 protein]; Quercetin inhibits the reaction [Ethanol results in increased secretion of MMP9 protein]; Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of MMP9 mRNA]; Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of MMP9 protein]; Quercetin promotes the reaction [Carbon Tetrachloride results in increased activity of MMP9 protein]; Quercetin promotes the reaction [Carbon Tetrachloride results in increased expression of MMP9 mRNA]PMID:14700523 PMID:16647178 PMID:22257724 PMID:22989100 PMID:26476374
MMP9multiple interactionsISOMmp9 (Mus musculus)6480464CTDDoxorubicin inhibits the reaction [Quercetin results in decreased activity of MMP9 protein]; Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of MMP9 mRNA]; Quercetin inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased activity of MMP9 protein]; Quercetin inhibits the reaction [Calcium Chloride results in increased activity of MMP9 protein]; Quercetin inhibits the reaction [Calcium Chloride results in increased expression of MMP9 mRNA]; Quercetin inhibits the reaction [Calcium Chloride results in increased expression of MMP9 protein]; Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]; Quercetin inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased activity of MMP9 protein]; Quercetin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Quercetin inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]PMID:14593496 PMID:16806698 PMID:19401153 PMID:19495926 PMID:22728078 PMID:22915297 PMID:24337353 PMID:37880698
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