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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348351
Species: Homo sapiens
RGD Object: Gene
Symbol: ACTA2
Name: actin alpha 2, smooth muscle
Acc ID: CHEBI:27584
Term: aldosterone
Definition: A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.
Chemical ID: MESH:D000450
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACTA2increases expressionEXP 6480464CTDAldosterone results in increased expression of ACTA2 mRNA; Aldosterone results in increased expression of ACTA2 proteinPMID:17596522
ACTA2multiple interactionsEXP 6480464CTDeplerenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 mRNA]; eplerenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein]; Rotenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 mRNA]; Rotenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein]; U 0126 inhibits the reaction [Aldosterone results in increased expression of ACTA2 mRNA]; U 0126 inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein]PMID:17596522
ACTA2increases expressionISOActa2 (Rattus norvegicus)6480464CTDAldosterone results in increased expression of ACTA2 proteinPMID:25204689
ACTA2multiple interactionsISOActa2 (Rattus norvegicus)6480464CTDSpironolactone inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein]; tempol inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein]PMID:25204689
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