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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348154
Species: Homo sapiens
RGD Object: Gene
Symbol: ITPA
Name: inosine triphosphatase
Acc ID: CHEBI:2948
Term: azathioprine
Definition: A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Chemical ID: MESH:D001379
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ITPAaffects response to substanceEXP 6480464CTDITPA gene polymorphism affects the susceptibility to Azathioprine; ITPA protein affects the susceptibility to AzathioprinePMID:15167706 PMID:15571265 PMID:16431304 PMID:19129747 PMID:19214663 PMID:21544018 PMID:21961091
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