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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347922
Species: Homo sapiens
RGD Object: Gene
Symbol: PCK1
Name: phosphoenolpyruvate carboxykinase 1
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PCK1decreases expressionEXP 6480464CTDPhenobarbital results in decreased expression of PCK1 mRNAPMID:21768169
PCK1multiple interactionsEXP 6480464CTD[Progesterone co-treated with Estradiol] inhibits the reaction [Phenobarbital results in decreased expression of PCK1 mRNA]; Estradiol inhibits the reaction [Phenobarbital results in decreased expression of PCK1 mRNA]; Progesterone inhibits the reaction [Phenobarbital results in decreased expression of PCK1 mRNA]PMID:21768169
PCK1affects expressionISOPck1 (Mus musculus)6480464CTDPhenobarbital affects the expression of PCK1 mRNAPMID:23091169
PCK1decreases activityISOPck1 (Rattus norvegicus)6480464CTDPhenobarbital results in decreased activity of PCK1 proteinPMID:8665939
PCK1decreases expressionISOPck1 (Mus musculus)6480464CTDPhenobarbital results in decreased expression of PCK1 mRNAPMID:19363144 PMID:19482888
PCK1decreases expressionISOPck1 (Rattus norvegicus)6480464CTDPhenobarbital results in decreased expression of PCK1 mRNAPMID:16510358
PCK1increases expressionISOPck1 (Mus musculus)6480464CTDPhenobarbital results in increased expression of PCK1 mRNAPMID:19270015
PCK1increases expressionISOPck1 (Rattus norvegicus)6480464CTDPhenobarbital results in increased expression of PCK1 mRNAPMID:19162173
PCK1multiple interactionsISOPck1 (Mus musculus)6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of PCK1 mRNA; NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of PCK1 mRNA]PMID:19482888 PMID:24535843
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