GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PCK1 | increases expression | EXP | | 6480464 | CTD | Dexamethasone results in increased expression of PCK1 mRNA; Dexamethasone results in increased expression of PCK1 protein | PMID:25047013 PMID:26616219 PMID:34273429 | PCK1 | multiple interactions | EXP | | 6480464 | CTD | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PCK1 mRNA; [Mifepristone co-treated with Dexamethasone] results in decreased expression of PCK1 mRNA; [monobutyl phthalate co-treated with Dexamethasone] results in increased expression of PCK1 mRNA; Mifepristone inhibits the reaction [Dexamethasone results in increased expression of PCK1 protein]; monobutyl phthalate promotes the reaction [Dexamethasone results in increased expression of PCK1 protein] | PMID:28628672 PMID:34273429 | PCK1 | decreases expression | ISO | Pck1 (Mus musculus) | 6480464 | CTD | Dexamethasone results in decreased expression of PCK1 mRNA | PMID:9518257 | PCK1 | increases expression | ISO | Pck1 (Rattus norvegicus) | 6480464 | CTD | Dexamethasone results in increased expression of PCK1 mRNA; Dexamethasone results in increased expression of PCK1 protein | PMID:1371108 PMID:15919808 PMID:23166830 | PCK1 | multiple interactions | ISO | Pck1 (Mus musculus) | 6480464 | CTD | [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of PCK1 mRNA; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PCK1 mRNA; [Cyclic AMP co-treated with Dexamethasone] results in increased expression of PEPCK protein; [Oleic Acid co-treated with Palmitic Acid] inhibits the reaction [INS1 protein inhibits the reaction [[Cyclic AMP co-treated with Dexamethasone] results in increased expression of PEPCK protein]]; arachidonyl-2-chloroethylamide inhibits the reaction [INS1 protein inhibits the reaction [[Cyclic AMP co-treated with Dexamethasone] results in increased expression of PEPCK protein]]; Cycloheximide inhibits the reaction [Dexamethasone results in decreased expression of PCK1 mRNA]; Dexamethasone inhibits the reaction [Clofibrate results in increased expression of PCK1 mRNA]; Dexamethasone inhibits the reaction [Isoproterenol results in increased expression of PCK1 mRNA]; Dexamethasone inhibits the reaction [Oleic Acid results in increased expression of PCK1 mRNA]; Dexamethasone inhibits the reaction [Rosiglitazone results in increased expression of PCK1 mRNA]; FOXO1 protein affects the reaction [[Oleic Acid co-treated with Palmitic Acid] inhibits the reaction [INS1 protein inhibits the reaction [[Cyclic AMP co-treated with Dexamethasone] results in increased expression of PEPCK protein]]]; FOXO1 protein affects the reaction [arachidonyl-2-chloroethylamide inhibits the reaction [INS1 protein inhibits the reaction [[Cyclic AMP co-treated with Dexamethasone] results in increased expression of PEPCK protein]]]; INS1 protein inhibits the reaction [[Cyclic AMP co-treated with Dexamethasone] results in increased expression of PEPCK protein]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [Clofibrate results in increased expression of PCK1 mRNA]]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [Rosiglitazone results in increased expression of PCK1 mRNA]] | PMID:23428407 PMID:24848799 PMID:26847930 PMID:9518257 | PCK1 | multiple interactions | ISO | Pck1 (Rattus norvegicus) | 6480464 | CTD | [Dexamethasone co-treated with Cyclic AMP] results in increased expression of PCK1 mRNA; Dexamethasone promotes the reaction [Colforsin results in increased expression of PCK1 mRNA]; Fatty Acids analog inhibits the reaction [[Dexamethasone co-treated with Cyclic AMP] results in increased expression of PCK1 mRNA]; Hydrogen Peroxide inhibits the reaction [[Dexamethasone co-treated with Cyclic AMP] results in increased expression of PCK1 mRNA]; Lithium Chloride inhibits the reaction [Dexamethasone results in increased expression of PCK1 mRNA]; sodium arsenite inhibits the reaction [[Dexamethasone co-treated with Cyclic AMP] results in increased expression of PCK1 mRNA] | PMID:1371108 PMID:22676303 PMID:25851902 PMID:8971075 | | ||||||||||||||||||||||
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