Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347893
Species: Homo sapiens
RGD Object: Gene
Symbol: HSD3B1
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Acc ID: CHEBI:63933
Term: Aroclor 1254
Definition: A mixture of polychlorobiphenyls of unspecified composition, containing 54% chlorine (X = Cl or H).
Chemical ID: MESH:D020111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSD3B1decreases activityISOHsd3b1 (Rattus norvegicus)6480464CTDChlorodiphenyl (54% Chlorine) results in decreased activity of HSD3B1 proteinPMID:19071209
HSD3B1decreases expressionISOHsd3b1 (Rattus norvegicus)6480464CTDChlorodiphenyl (54% Chlorine) results in decreased expression of HSD3B1 mRNA; Chlorodiphenyl (54% Chlorine) results in decreased expression of HSD3B1 proteinPMID:17280759 PMID:29208485
HSD3B1multiple interactionsISOHsd3b1 (Rattus norvegicus)6480464CTDAscorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of HSD3B1 mRNA]; lycopene inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of HSD3B1 protein]; Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of HSD3B1 mRNA]PMID:17280759 PMID:19071209
Go Back to source page   Continue to Ontology report