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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347408
Species: Homo sapiens
RGD Object: Gene
Symbol: MIRLET7F2
Name: microRNA let-7f-2
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MIRLET7F2increases expressionISOMirlet7f2 (Rattus norvegicus)6480464CTDDoxorubicin results in increased expression of MIRLET7F-2 mRNAPMID:31570982
MIRLET7F2multiple interactionsISOMirlet7f2 (Rattus norvegicus)6480464CTDDoxorubicin affects the reaction [MIRLET7F-2 mRNA affects the localization of HAX1 protein]; Doxorubicin promotes the reaction [MIRLET7F-2 mRNA results in decreased expression of XPO1 mRNA]; Doxorubicin promotes the reaction [MIRLET7F-2 mRNA results in decreased expression of XPO1 protein]; Doxorubicin promotes the reaction [MIRLET7F-2 mRNA results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [MIRLET7F-2 mRNA results in increased cleavage of CASP9 protein]; MIRLET7F-2 mRNA affects the reaction [Doxorubicin affects the localization of HAX1 protein]; MIRLET7F-2 mRNA affects the reaction [Doxorubicin results in decreased expression of XPO1 protein]; MIRLET7F-2 mRNA affects the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; MIRLET7F-2 mRNA affects the reaction [Doxorubicin results in increased cleavage of CASP9 protein]; MIRLET7F-2 mRNA inhibits the reaction [NEAT1 mRNA inhibits the reaction [Doxorubicin results in decreased expression of XPO1 mRNA]]; MIRLET7F-2 mRNA inhibits the reaction [NEAT1 mRNA inhibits the reaction [Doxorubicin results in decreased expression of XPO1 protein]]; NEAT1 mRNA inhibits the reaction [Doxorubicin results in increased expression of MIRLET7F-2 mRNA]PMID:31570982
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