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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347215
Species: Homo sapiens
RGD Object: Gene
Symbol: TIMP1
Name: TIMP metallopeptidase inhibitor 1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TIMP1decreases expressionEXP 6480464CTDQuercetin results in decreased expression of TIMP1 mRNA; Quercetin results in decreased expression of TIMP1 proteinPMID:11506819
TIMP1increases expressionEXP 6480464CTDQuercetin results in increased expression of TIMP1 mRNA; Quercetin results in increased expression of TIMP1 proteinPMID:11414687 PMID:21632981
TIMP1multiple interactionsEXP 6480464CTDQuercetin promotes the reaction [Cholesterol, LDL results in increased expression of TIMP1 mRNA]; Quercetin promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of TIMP1 mRNA]PMID:11414687
TIMP1multiple interactionsISOTimp1 (Rattus norvegicus)6480464CTD[Quercetin co-treated with Carbon Tetrachloride] results in increased expression of TIMP1 mRNAPMID:22989100
TIMP1multiple interactionsISOTimp1 (Mus musculus)6480464CTDQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TIMP1 mRNA]; Quercetin inhibits the reaction [Calcium Chloride results in decreased expression of TIMP1 mRNA]PMID:22728078 PMID:22915297
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