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GENE - TERM ANNOTATION REPORT

RGD ID: 1347174
Species: Homo sapiens
RGD Object: Gene
Symbol: ACE2
Name: angiotensin converting enzyme 2
Acc ID: DOID:2945
Term: severe acute respiratory syndrome
Definition: A Coronavirus infectious disease that results_in infection located_in respiratory tract, has_material_basis_in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome "DO" "DO", http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=SARS "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACE2susceptibilityIMP 30309965RGDhuman gene in a mouse model 
ACE2treatmentIMP 32716426RGDhuman gene in a mouse model 
ACE2 ISOAce2 (Mus musculus)40818405RGDmRNA, protein:decreased expression:heart (mouse) 
ACE2severityISOAce2 (Mus musculus)30309202RGD  
ACE2 EXP 11554173CTDCTD Direct Evidence: marker/mechanismPMID:14647384 PMID:16007097 PMID:16166518 PMID:16339146 PMID:19453650 PMID:19625462 PMID:23678171 PMID:24172901 PMID:24227843 PMID:26801988 PMID:31996437 PMID:32092392 PMID:32201080
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