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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346909
Species: Homo sapiens
RGD Object: Gene
Symbol: SLC13A1
Name: solute carrier family 13 member 1
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SLC13A1increases expressionEXP 6480464CTDAcetaminophen results in increased expression of SLC13A1 mRNAPMID:22230336
SLC13A1increases response to substanceISOSlc13a1 (Mus musculus)6480464CTDSLC13A1 gene mutant form results in increased susceptibility to AcetaminophenPMID:16729303
SLC13A1multiple interactionsISOSlc13a1 (Mus musculus)6480464CTDAcetaminophen affects the reaction [SLC13A1 protein affects the abundance of Sulfates]; SLC13A1 protein affects the reaction [Acetaminophen affects the expression of SLC26A1 mRNA]; SLC13A1 protein affects the reaction [Acetaminophen results in increased expression of CYP1A2 mRNA]; SLC13A1 protein affects the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; SLC13A1 protein affects the reaction [Acetaminophen results in increased expression of CYP3A11 mRNA]; SLC13A1 protein affects the reaction [Acetaminophen results in increased expression of GSTP1 mRNA]PMID:16729303
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