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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346751
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2B6
Name: cytochrome P450 family 2 subfamily B member 6
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2B6affects expressionISOCyp2b3 (Rattus norvegicus)6480464CTDCarbon Tetrachloride affects the expression of CYP2B3 mRNAPMID:12734012
CYP2B6decreases expressionISOCyp2b3 (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in decreased expression of CYP2B3 mRNA; Carbon Tetrachloride results in decreased expression of CYP2B3 proteinPMID:17606319 PMID:31150632
CYP2B6increases expressionISOCyp2b10 (Mus musculus)6480464CTDCarbon Tetrachloride results in increased expression of CYP2B10 mRNAPMID:16273607 PMID:18038451 PMID:29987408
CYP2B6multiple interactionsISOCyp2b10 (Mus musculus)6480464CTD[Carbon Tetrachloride co-treated with Tamoxifen] affects the expression of CYP2B10 mRNA; NR1I3 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2B10 mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of CYP2B10 mRNA]PMID:16273607 PMID:18038451 PMID:29974145
CYP2B6multiple interactionsISOCyp2b3 (Rattus norvegicus)6480464CTDschizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2B3 mRNA]PMID:31150632
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