Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346665
Species: Homo sapiens
RGD Object: Gene
Symbol: TNFRSF10B
Name: TNF receptor superfamily member 10b
Acc ID: CHEBI:18145
Term: (R,R,R)-alpha-tocopherol
Definition: An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.
Chemical ID: MESH:D024502
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFRSF10Bincreases expressionEXP 6480464CTDalpha-Tocopherol analog results in increased expression of TNFRSF10B mRNA; alpha-Tocopherol analog results in increased expression of TNFRSF10B proteinPMID:20686688
TNFRSF10Bmultiple interactionsEXP 6480464CTDbenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in increased expression of TNFRSF10B protein]; salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased expression of TNFRSF10B protein]; TNFRSF10B mRNA affects the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein]PMID:20686688
Go Back to source page   Continue to Ontology report