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GENE - TERM ANNOTATION REPORT

RGD ID: 1346515
Species: Homo sapiens
RGD Object: Gene
Symbol: DHFR2
Name: dihydrofolate reductase 2
Acc ID: GO:0004146
Term: dihydrofolate reductase activity
Definition: Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.
Definition Source(s): EC:1.5.1.3
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DHFR2enablesIBACGD:CAL0000177250 or FB:FBgn0004087 or MGI:94890 or PANTHER:PTN000167322 or PomBase:SPCC1223.08c or Dhfr (Rattus norvegicus) or SGD:S000005762 or UniProtKB:P00374 or UniProtKB:P0ABQ4 or UniProtKB:P9WNX1 or UniProtKB:Q86XF0 or ZFIN:ZDB-GENE-010406-5 or dictyBase:DDB_G0286755150520179GO_Central GO_REF:0000033
DHFR2enablesIEAInterPro:IPR001796 or InterPro:IPR012259150520179InterPro GO_REF:0000002
DHFR2enablesIEARHEA:15009150520179RHEA GO_REF:0000116
DHFR2enablesIEAPANTHER:PTHR48069:SF1150520179TreeGrafter GO_REF:0000118
DHFR2enablesIEAARBA:ARBA00028044150520179UniProt GO_REF:0000117
DHFR2enablesIEAEC:1.5.1.3150520179UniProt GO_REF:0000003
DHFR2enablesIMP 150520179UniProt PMID:21876188

PMID:21876188
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